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ARRIVE guidelines statement : The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines

JAMIA Open 3 , 536544 (2020)

Immunoglobulin G Following birth, exposure to diverse microbial antigens stimulates the developing immune system, leading to a progressive increase in endogenous IgG production

Although the aged brain does have increases in ROS, pro-inflammatory cytokines, and a general reduction in glial cell function, the extent of these changes and the dynamics at play are inherently different than those observed after the application of LPS or experimentally-induced demyelination at younger ages

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Measurement of CB1-R binding and its coupling to G proteins revealed higher stimulation by CB1 receptor agonists of [35S] GTPcS binding both in the caudate and putamen, along with an enhanced CB1 receptor binding [78]